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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Ginsenoside Rg1, Doxorubicin
Phytochemical Name Ginsenoside Rg1 (PubChem CID: 441923 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 208
Ref_1
Pair Name Ginsenoside Rg1, Doxorubicin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression AKT1 hsa207
Up-regulation Expression APAF1 hsa317
Up-regulation Expression ATM hsa472
Up-regulation Expression BAX hsa581
Up-regulation Expression CASP3 hsa836
Up-regulation Expression CASP9 hsa842
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression H2AX hsa3014
Down-regulation Expression MAPK1 hsa5594
Up-regulation Expression RAD51 hsa5888
Up-regulation Expression ROS1 hsa6098
Up-regulation Expression TP53 hsa7157
Up-regulation Expression XRCC1 hsa7515
In Vitro Model MDA-MB-231 Breast adenocarcinoma Homo sapiens (Human) CVCL_0062
Result The present results support the chemosensitizing property of ginsenoside Rg1 in triple-negative breast cancer cell lines.
03. Reference
No. Title Href
1 Ginsenoside RG1 augments doxorubicin-induced apoptotic cell death in MDA-MB-231 breast cancer cell lines. J Biochem Mol Toxicol. 2022 Jan;36(1):e22945. doi: 10.1002/jbt.22945. Click
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